You can rent a car almost anywhere in the Yucatan. The easiest and cheapest place to rent a vehicle is Playa del Carmen.
It has been our experience that every resort will have at least one car rental agency in the lobby. You will find quite often the person speaks Spanish only. Also they are not always at their post and can sometimes be hard to find. Some agencies have booths but have no personnel. The resort agencies usually do not have any maps and if they do it is usually the Maya Riviera hotel guide, which has an okay map in it.
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If you are staying in Cancun you will find it cheaper to rent a car at the airport or take a taxi to the shopping zone where you will find a number of rental agencies. You will find the cost of renting a car here considerably less than your resort agency.
If you are staying on the Maya Riviera take a Mexican bus or taxi to Playa del Carmen and rent your car there. It will be considerably less; almost everybody at every agency speaks English. The agencies have good maps as well.
For people staying in Merida you will find many agencies based downtown or out of the airport so if you are flying in it is wise to simply book your car at the airport when you arrive. They will deliver the car to you at your hotel on the day you want it or you may be able to drive away if the car you want is there.
If you stay at the Reef Club or anywhere near Progreso rent your car at the airport and save yourself the aggravation of doing everything over the phone. They will have personnel who can speak English at the airport. Do NOT rely on a representative being at the Reef Club.
NOTE: Get your map at the airport. The map you will find at the airport is in a newsprint travel guide called “Yucatan Today”. The tour rep at Reef Club has an okay map as well.
Some hotels have old maps that are good.
Outside of Chetumal there is no place to rent a car so you either rent one at Cancun airport and drive to Chetumal or you fly into Chetamal and rent a car at Chetumal airport or Chetumal city. Finding a map here could be tricky and it is recommended that you find one before you go.
Finding a car rental agency in Campeche is not easy. The only car rental agency we could find was located in the lobby of Hotel Baluartes [on Ruiz Cortines]. The reservation clerk was not at his post the first day we looked and there was no phone number to call. The second day he was there.